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WHO Monkeypox Research - What study designs can be used to address the remaining knowledge gaps for monkeypox vaccines? - World Health Organization

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Date: Tuesday 2 August, 2022

Time: 13:00 to 18:00 CET

Registration link : https://who-e.zoom.us/webinar/register/WN_rf-TRQ_sQgW99RC7i8znpQ

The WHO R&D Blueprint is organizing a consultation to discuss knowledge gaps and priority research questions for monkeypox vaccine research.

OBJECTIVES

The Director-General of WHO decided that the global monkeypox outbreak represents a public health emergency of international concern. [Source: WHO Director-General's press statement]

WHO is recommending that Member States make all efforts to use existing or new vaccines against monkeypox within a framework of collaborative clinical efficacy studies, using standardized design methods and data collection tools for clinical and outcome data, to rapidly increase evidence generation on efficacy and safety, collect data on effectiveness of vaccines (e.g., such as comparison of one or two dose vaccine regimens), and conduct vaccine effectiveness studies.  [Source:Second meeting of the International Health Regulations (2005) (IHR) Emergency Committee regarding the multi-country outbreak of monkeypox]

To facilitate the implementation of the above recommendations, the WHO R&D Blueprint for epidemics is organizing a global consultation to discuss monkeypox vaccine research. 

What study designs can be used to address the remaining knowledge gaps for monkeypox vaccines? 

During this forthcoming consultation global experts will review the available evidence in terms of:

  • Overview of potential study designs.
  • Plans to evaluate vaccine efficacy/effectiveness of monkeypox vaccines in different countries.
  • Optimal strategies for the design of randomised and non- randomised studies for vaccine efficacy and effectiveness.

EXPECTED OUTCOMES

  • Consensus critical attributes of optimal study designs
  • Outline of the next steps to share information on plans to evaluate and on emerging results

Agenda will be shared soon.

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WHO Monkeypox Research - What study designs can be used to address the remaining knowledge gaps for monkeypox vaccines? - World Health Organization
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